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Instrumentation – EARO

Instrumentation

EARO offers a wide range of state-of-the-art technologies in compound storage & management, liquid handling workflows, automation of biochemical, cell- and image-based assays to fast-track your target validation, hit-finding, and most other nodes of early-stage drug discovery phases.

Leverage our technologies by getting supervised/unsupervised access to these instruments with complete walkaway automation or the modular formats for maximum control.

Compound Storage and Management System

Azenta SampleStore II

Azenta SampleStore II

The Azenta Life Sciences SampleStore II at EARO has a 9000 SBS plates sample storage capacity and throughput. The design maintains the compounds in ideal anhydrous environment for the rest of their shelf life and automatically dispenses desired volumes in desired formats for collection or automated future processing.

  • Can accommodate 9000 standard height SBS-format plates or 30,000 matrix tubes
  • Fits the widest range of labware
  • Dynamic storage shelving
  • Pick rates of over 100,000 tubes in 24 hours
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  • Labware flexibility and adaptability handles the widest range of labware available in a single store, including SBS-format plates, tubes, cryovials
  • Picking modules allow the system to handle sample labware and throughput requirements
  • Sample security maintains inventory, environment tracking and consistent storage temperatures
  • High-density storage and Multi-pitch shelving can more than double storage capacity compared to SBS format storage
  • High throughput dual-shuttle automation doubles standard throughput rates, supporting pick rates of over 100,000 tubes in 24 hours
  • Acoustic tube capability picks Acoustic Sample Tube, which is Echo Qualified
  • Automation Interface provides a means of directly interfacing the store with an external automation systems

Complete Process Integration

Beckman Automation Deck

Beckman Automation Deck

A fully programmable hands-free integrated system for high throughput end-to-end drug screening walk-away workflows.

On the Deck:

  • Biomek i5
  • Brooks Xpeel
  • Agilent PlateLoc
  • Agilent Barcode Labeler
  • Labcyte Echo 650
  • Thermo Multidrop Combi
  • Thermo Cytomat 10
  • BioTek EL406
  • Tecan Spark

Applications:

  • End-to-end Screening Workflows
    • Cell Seeding
    • Compound Treatment
    • Incubation
    • Reagent Dispensing
    • Plate Washing
    • Assay Readouts

 

 

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  • Biomek i5 to optimise liquid handling dependability and walk-away time
  • Azenta Brooks Xpeel automatically removes seals from a wide range of microplate, eliminating the need for repetitive, manual removal of plate seals, and the need for lids, preserving sample integrity
  • Agilent PlateLoc is a premier fully automatic thermal heat sealer which accommodates deep-well, assay, PCR, and compound storage microplates with a variety of seals for different applications
  • Agilent Barcode Labeller is capable of labelling all four sides of a microplate and delivers the speed, flexibility, and dependability that allow users to achieve their throughput goals
  • Thermo Multidrop Combi is a versatile reagent dispenser with excellent performance for drug discovery or genomic and proteomic assays
  • Biotek EL406 washer dispenser is a fast, full plate washer with three reagent dispensers. It is capable of washing and dispensing plates for standard assays, biomagnetic separation and vacuum filtration protocols
  • Tecan Spark is a multimode plate reader for kinetic and end-point assay readout, completely integrated with all other instruments on the deck
  • Thermo Cytomat 10 is a fast access automated incubator that can fit up to 500 cell culture SBS plates medium-large scale cell biology screening projects, seamlessly integrated with existing automated assay hardware
  • Labcyte Echo 650 Acoustic Liquid Handler is ideal for high-throughput applications. It transfers volumes as little as 2.5 nL from 384-well and 1536-well microplates
  • SAMI Ex Scheduling Software provides complete automation and process control across a wide variety of applications for planned data-driven schedules in a predictable scheduling environment

Automated Liquid Handling Decks

Agilent DDR Deck

Agilent DDR Deck

A fully programmable hands-free liquid handling integration. Ideal for library reformatting and assay plate preparation.

On the Deck:

  • Brooks Xpeel
  • Agilent PlateLoc
  • Agilent Labware Stacker
  • Agilent Plate Centrifuge
  • Agilent Bravo
  • 2D Barcode Reader
  • Agilent VWorks Scheduling Software
Applications:

  • Library Reformatting
  • Assay Plate Preparation
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  • Azenta Brooks Xpeel automatically removes seals from a wide range of microplate, eliminating the need for repetitive, manual removal of plate seals, and the need for lids, preserving sample integrity
  • Agilent PlateLoc is a premier fully automatic thermal heat sealer which accommodates deep-well, assay, PCR, and compound storage microplates with a variety of seals for different applications
  • Agilent Labware Stacker is a sequential microplate stacker that receives and dispenses microplates and other labware in laboratory automation systems. It can manage a variety of labware, including deep-well and shallow-well plates, pin tools, tip boxes, and lids
  • Agilent Plate Centrifuge is a small, robot-accessible automated centrifuge with customisable acceleration and deceleration, minimising the required cycle time
  • Agilent Bravo liquid handler automates sample preparation for screening applications such as compound management, cell-based assays, and biochemical assays
  • 2D Barcode Reader reliably scans barcodes at high speeds with a broad depth of field
  • Agilent DDR is a state-of-the-art robotic arm that reduces the number of moving parts, resulting in increased reliability and speed, moving smoothly with precision and accuracy
  • Agilent VWorks Scheduling software is a laboratory integration and automation interface. It connects diverse devices such as robotics, liquid handlers, readers, and washers into one cohesive, integrated system that ensures maximum throughput and optimal resource utilisation
Agilent Bravo Deck (Laminar Flow Enclosed)

Agilent Bravo Deck (Laminar Flow Enclosed)

A fully programmable hands-free liquid handling integration enclosed in a laminar flow environment. Ideal for library reformatting, assay plate preparation, and library drug treatments in a sterile environment.

On the Deck:

  • Agilent Bravo
  • Agilent BenchCel 4R
  • Agilent PlateLoc
  • Agilent Labeler
  • 2D Barcode Reader
  • Agilent VWorks Scheduling Software
Applications:

  • Library Reformatting
  • Assay Plate Preparation
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  • Agilent Bravo is a flexible liquid handling platform that automates your sample preparation for screening applications such as compound management, cell-based assays, and biochemical assays
  • Agilent BenchCel 4R is a microplate storage and automated microplate handling system. It features a high-speed robot, and its modular design provides the flexibility and scalability required to meet the needs of the most diverse laboratory applications
  • Agilent PlateLoc is a premier fully automatic thermal heat sealer, featuring an intuitive and easy-to-use interface, it accommodates deep-well, assay, PCR, and compound storage microplates with a variety of seals for different applications
  • Agilent Barcode Labeler is capable of labelling all four sides of a microplate and delivers the speed, flexibility, and dependability that allow users to achieve their throughput goals
  • 2D Barcode Reader reliably scans barcodes at high speeds with a broad depth of field
  • Agilent VWorks Scheduling software is a laboratory integration and automation interface. It connects diverse devices such as robotics, liquid handlers, readers, and washers into one cohesive, integrated system that ensures maximum throughput and optimal resource utilisation
  • Laminar Airflow Enclosure provides a clean environment to handle you cell-based experiments minimising cross-contamination between samples and safety to the operator
Perkin Elmer JANUS Deck (Laminar Flow Enclosed)

Perkin Elmer JANUS Deck (Laminar Flow Enclosed)

A fully programmable hands-free liquid handling integration single tip customisation on a very large deck. The setup is enclosed within a laminar flow environment for clean zone operations. Ideal for a large array of liquid handing workflows in genomics, proteomics, and the standard drug screening workflows – cherry-picking, library reformatting, assay plate preparation, and library drug treatments.

On the Deck:

  • Perkin Elmer Janus Gripper
  • Perkin Elmer 8-channel Varispan
  • Perkin Elmer PlatStak
  • Perkin Elmer MDT Arm
  • LiCoNiC Plate Hotel
  • Perkin Elmer WinWorks Scheduling Software
Applications:

  • Library Reformatting
  • Assay Plate Preparation
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  • Perkin Elmer Janus Gripper automated workstation is designed for the efficient automation of sample preparation procedures utilised in pharmaceutical, biotech and research applications. The instrument consists of a modular platform that enables one pipetting arm with different tip configurations as well as one plate movement arm on a single workstation. Liquid transfers can be performed in a multi-tipped mode from any combination of laboratory containers including 384-well formats for complete and flexible assay automation
  • Perkin Elmer 8-channel Varispan is an 8-tip dispensing arms provide independent variable sample probe spacing for multi-tipped processing of test tubes, microplates, deep well plates, vials, and customised labware
  • Perkin Elmer MDT Arm offers multi-channel dispensing with on the fly 96-/384-head adaptability in dynamic volume range and microplate densities
  • Perkin Elmer PlateStak microplate handler is a solution for addressing increased capacity and unattended processing needs by automating the handling and storage of microplates and tip boxes. The system incorporates a bi-directional shuttle that transports microplates or tip boxes from cassette to cassette or to programmable locations on the diving board. The diving board extends out from the PlateStak automated microplate handler, making the microplates available on the working deck of the JANUS workstation
  • LiCONiC Plate Hotel is compatible with a wide selection of microplates and tip boxes for laboratory automation
  • Laminar Airflow Enclosure provides a clean environment to handle you cell-based experiments minimising cross-contamination between samples and safety to the operator

High-Content Imaging

Perkin Elmer Opera Phenix

Perkin Elmer Opera Phenix

A premier High Content Screening System confocal solution equipped with dual cameras and four solid state lasers delivering speed without compromising sensitivity for the most demanding high content applications that require detailed descriptions of cellular morphology, subcellular details, and differentiation of cellular phenotypes

Applications:

  • High-throughput high-content assays
  • Phenotypic screening
  • Phenotypic Fingerprinting/Cell Painting
  • Protein-Protein Interactions (FRET)
  • Assays using complex disease models
  • Cell lines/Primary cells/Microtissues/Spheroid/Organoid Screening
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  • Two large format sCMOS cameras configuration with four solid state lasers for simultaneous acquisition generating images of exceptional quality faster
  • Spinning disk with dual view confocal optics to separate fluorescence excitation and emission during simultaneous acquisition minimising spectral crosstalk for greater speed and higher sensitivity
  • High NA water immersion objectives to capture more photons and provide high image resolution even in thick samples
  • Widefield or confocal imaging modes depending on your assay requirements
  • PlateHandler II robotic arm is programmable to automated up to 28 plates
  • Intuitive Harmony software user-interface for easy acquisition, analysis and evaluation
  • Ready-made solutions for common image analysis tasks
  • Image analysis building blocks that allow you to create, configure, and customise your own high content analysis applications
  • Web-based Columbus Image Data Storage and Analysis for automatic storage of analysis results and metadata, such as assay layout, instrument, settings, and annotations
Perkin Elmer Operetta CLS

Perkin Elmer Operetta CLS

A versatile High Content Screening System with 8x LED light source and 8x emission filters to accommodate a very wide range of fluorophores. The confocal and widefield fluorescence configuration offers flexibility in excitation and imaging modes for many challenging applications to capture subtle changes in cellular morphology, subcellular details, and differentiation of cellular phenotypes.

Applications:

  • High-throughput high-content assays
  • Phenotypic screening
  • Fixed-cell Assays
  • Live-cell Assays
  • Time-lapse Assays
  • Phenotypic Fingerprinting/Cell Painting
  • Assays using complex disease models
  • Cell lines/Primary cells/Microtissues/Spheroid/Organoid Screening
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  • Powerful, stable 8x LED light source for optimal excitation of your fluorophores and confidence in results
  • Water-immersion objectives with very high numerical aperture enable high resolution and fast read times with minimal photodamage
  • Confocal spinning disk technology provides a fast and gentle imaging process, enabling efficient background rejection, live-cell experiments, and 3D imaging
  • Large format sCMOS camera delivers low noise, wide dynamic range, and high resolution – perfect for sensitive and quantitative measurements at short exposure times
  • Widefield or confocal imaging modes depending on your assay requirements
  • PlateHandler II robotic arm is programmable to automated up to 28 plates
  • Intuitive Harmony software user-interface for easy acquisition, analysis and evaluation
  • Ready-made solutions for common image analysis tasks
  • Image analysis building blocks that allow you to create, configure, and customise your own high content analysis applications
  • Web-based Columbus Image Data Storage and Analysis for automatic storage of analysis results and metadata, such as assay layout, instrument, settings, and annotations

Non-contact Compound Spotting

LabCyte Echo 550

LabCyte Echo 550

A low-volume acoustic liquid handling platform with no tips and no cross-contamination. The instrument can easily switch between different fluid types.

Applications:

  • siRNA Screening
  • Compound Screening
  • Dose Response Treatment
  • Combination Screening
  • Biochemical/Cell-based Assays
  • PCR Reactions
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  • Compatible with liquids with challenging properties – volatile, low-surface tension and/or meniscus-shifting fluids
  • Volumetric accuracy and precision for all fluids – including buffers, nucleic acid and protein solutions, surfactants, serum and cell culture media
  • Low-volume liquid handling in 2.5 nL increments from Echo-qualified 384- and 1536-well source plates into 96-, 384-, 1536- and 3456-well destination plates
  • Touchless technology eliminates consumable tips, washing, and cross-contamination

Microplate Washers & Dispensers

BioTek 405 TS Washer with BioStack

BioTek 405 TS Washer with BioStack

The 405 TS washer efficiently wash cell-based assays, microsphere-based assays, and ELISA applications. Operation via the touchscreen interface is intuitive and simple and it automatically checks and cleans manifold tube blockages before a wash cycle.

The BioStack can automate workflows up to 30 microplates.

Applications:

  • ELISA
  • ELISpot Assays
  • Immunohistochemistry
  • Cell-based Assays
  • Magnetic and bead-based assays
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  • Excellent microplate washer compatible with 96- and 384-well formats
  • Cell-friendly design for high quality results
  • Self-maintaining design with patented ultrasonic bath
  • Hands-off self-testing technology
BioTek MultiFlo FX Dispenser

BioTek MultiFlo FX Dispenser

MultiFlo FX is an automated multimode reagent dispenser for 6- to 1536-well microplates. One of the FX units incorporates parallel dispense and random access dispense (RAD) modules. The technologies in MultiFlo FX microplate dispenser enable many liquid handling applications. from 2D and 3D cell culture to concentration normalisation assays, ELISA, bead-based assays and more. A fully configured MultiFlo FX replaces up to five liquid handlers, saving space, time, and instrumentation budgets. MultiFlo FX delivers complete workflow automation in cell imaging and biochemical applications.The 405 TS washer efficiently wash cell-based assays, microsphere-based assays, and ELISA applications. Operation via the touchscreen interface is intuitive and simple and it automatically checks and cleans manifold tube blockages before a wash cycle.

The BioStack can automate workflows up to 30 microplates.

Applications:

  • 2D/3D Cell Culture
  • Reagent Dispensing
  • ELISA
  • Concentration Normalisation Assays
  • Immunohistochemistry
  • Cell-based Assays
  • Magnetic and bead-based assays
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  • Cell friendly angled dispense and/or wash tubes
  • Automated, gentle media exchange and spheroid washing
  • Mapped dispensing to individual wells for normalisation
  • Compatible with 6- to 384-well plates
  • Peristaltic Parallel Dispense technology

Automated Histology Slide Scanner

Akoya Biosciences Vectra Polaris

Akoya Biosciences Vectra Polaris

Vectra Polaris is an automated multispectral imaging system used for whole-slide scanning. Automated Quantitative Pathology. It goes beyond conventional brightfield and fluorescence whole-slide scanning when using the 6-plex, 7 colour Opal Polaris kit which enables the biology to be explored at multiple scales, from cell-to-cell interactions to the macroscopic tissue architecture.

Applications:

  • Multispectral Imaging
  • Whole Slide Scanning
  • Tumour Microenvironment
  • Automated Quantitative Pathology
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  • Create simple and robust workflows as fields of view do not need to be selected eliminating selection bias. No re-scans required, easily re-analyse imagery as new understanding emerges
  • Label tissue sections or TMAs with immunofluorescent (IF) or immunohistochemical (IHC) stains such as Opal, or with conventional stains such as H&E and trichrome
  • MOTiF technology generates unmixed whole slide scans at 40x magnification of up to 7 colours for analysis of biology across the entire slide in a streamlined workflow and without selection bias
  • Fully automated, high-throughput system to accelerate your research
  • High speed digital whole-slide scanning at 10x – 40x in brightfield or fluorescence
  • Enclosed system with built-in touchless automation
  • Integrated tissue analysis software for biomarker quantification and spatial analysis

Image Flow Cytometry

Amnis ImageStreamX MkII

Amnis ImageStreamX MkII

A benchtop Imaging Flow Cytometer that combines the speed, sensitivity, and phenotyping abilities of flow cytometry with the detailed imagery and functional insights of microscopy. By collecting large numbers of digital images per sample and providing a numerical representation of image-based features, the system combines the per cell information from microscopy with the statistical significance afforded by large sample sizes from flow cytometry. This unique combination enables measurement of fluorescence intensities alongside location and quantitative distribution of signals on in or between cells.

Applications:

  • FACS
  • Nuclear Translocation
  • Colocalisation
  • FISH
  • Autophagy
  • Spot Counting
  • Exosome/Extracellular Vesicles (EVs)
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  • Fast: Analyse up to 5000 cells/sec with real-time intensity compensation
  • 60x, 40x, 20x Magnification
  • Extended Depth of Field (EDF) to project more structures within the cell into one crisp plane of focus
  • AutoSampler for Multiwell Plates
  • Easy-to-Use intuitive user interface provides real-time plotting and graphical gating, as well as images of every cell Compensation wizard quickly guides you through setup of multi-colour compensation matrices
  • Has 3 lasers and works with sample volumes of 20-200 µL
  • Efficient Fluidics that provide up to 95% sample utilisation when every cell is required. Recover unused sample for further analysis when orthogonal methods are required

High Throughput Plate Readers

Tecan Spark Multimode Reader with Spark-Stack

Tecan Spark Multimode Reader with Spark-Stack

A versatile multimode microplate reader suited measurement and data analysis of absorbance, fluorescence, time resolved fluorescence, fluorescence polarisation and luminescence of biological and non-biological samples. the reader is suited for both endpoint and kinetic measurements with either single or multi-label measurements. The set up can automate up to 50 plate at once.

Read Modes/Applications:

  • ABS – Absorbance
  • FL -Fluorescence
  • TRF – Time Resolved Fluorescence
  • FRET – Fluorescence Resonance Energy Transfer
  • TR-FRET – Time-Resolved Fluorescence Resonance Energy Transfer
  • FP – Fluorescence Polarisation
  • LUMI – Luminescence
  • Absorbance cuvette port
  • NanoQuant plate
  • Integrated lid handling
  • BRET, NanoBRET
  • Low-volume DNA/RNA quantification
  • Nucleic acid labelling efficiency
  • Protein quantification
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Tecan Infinite M1000 Pro with Stacker

Tecan Infinite M1000 Pro with Stacker

A multifunctional monochromator-based microplate reader that provides high performance for many microplate applications. versatile multimode microplate reader suited measurement and data analysis of absorbance, fluorescence, time resolved fluorescence, fluorescence polarisation and luminescence of biological and non-biological samples. the reader is suited for both endpoint and kinetic measurements with either single or multi-label measurements. The set up can automate up to 50 plate at once.

Read Modes/Applications:

  • ABS – Absorbance
  • FL -Fluorescence
  • TRF – Time Resolved Fluorescence
  • FRET – Fluorescence Resonance Energy Transfer
  • TR-FRET – Time-Resolved Fluorescence Resonance Energy Transfer
  • FP – Fluorescence Polarisation
  • LUMI – Luminescence
  • ALPHA – AlphaScreen, AlphaLISA
  • Low-volume DNA/RNA quantification
  • Nucleic acid labelling efficiency
  • Protein quantification
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